Toxin-coregulated pilus

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August undefined, 2024

WebAug 26, 2014 · Structure of the Cytoplasmic Domain of TcpE, the Inner Membrane Core Protein Required for Assembly of the Vibrio cholerae Toxin-coregulated Pilus. United States: N. p., 2014. United States: N. p., 2014. WebFeb 1, 2010 · Vibrio cholerae is a Gram-negative bacterium and the causative agent of the acute intestinal infection known as cholera. Upon entry into the host intestine, V. cholerae induces a transcriptional cascade resulting in the expression of the master virulence regulator, ToxT. ToxT directly activates the expression of the two primary virulence …

TCP - Toxin-Coregulated Pilus AcronymFinder

WebDaxi Sun is an academic researcher from University of Tennessee Health Science Center. The author has contributed to research in topic(s): Pilus & Vibrio cholerae. The author has an hindex of 3, co-authored 3 publication(s) receiving 126 citation(s). WebApr 17, 2024 · Cholera toxin (CT) and toxin coregulated pilus (TCP, TcpA is the major subunit) are two major virulence factors of Vibrio cholerae, both of which play critical … gel foam for wounds

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WebFor example, the major toxin-coregulated pilus (TCP) gene, tcpA, of the TCP cluster possesses classical- and El Tor-specific alleles that encode identical functions but differ … WebNational Center for Biotechnology Information WebJan 7, 1997 · Cholera toxin (CT) is a multimeric protein composed of one A subunit and five B subunits encoded by the ctxAB operon ( 1 ). Coordinately expressed with CT is the toxin-coregulated pilus (TCP) ( 2 ), which plays a major role … gelfoam hemostatico

Structural basis for the toxin-coregulated pilus-dependent secretion of ...

Intestinal Colonization Dynamics of Vibrio cholerae - PLOS

WebMar 10, 1994 · The pilus is designated TCP, for toxin-coregulated pilus, and the pilin subunit is designated TcpA. Fusions to genes tcpBCDEF show reduced levels of pilin and lack pili … WebDeletion of toxR, the gene encoding the cholera toxin-positive regulatory protein resulted in a diminution in colonizing capacity. A deletion mutation in tcpA, encoding the major subunit of the toxin coregulated pilus (regulated by toxR), abolished the colonizing capacity of … ddg airportWebFeb 19, 2002 · We focused on the regulators LuxO and HapR because homologues of these two proteins control quorum sensing in the closely related luminous marine bacterium … gelfoam indications

"Webtoxin coregulated pilus biosynthesis protein H toxin coregulated pilus biosynthesis protein T vpsU tyrosine-protein phosphatase vpsA vc0918 vpsB vpsC serine O-acetyltransferase rbmA rbmC vpsL znuA zinc transport system substrate-binding protein znuC zinc transport system ATP-binding protein znuB zinc transport system permease protein prsA " - Toxin-coregulated pilus

Toxin-coregulated pilus

WebApr 5, 2024 · The host receptor for the CTXφ phage is the toxin-coregulated (TCP) type IV bundle-forming pilus, which itself is an important virulence factor. ... Mekalanos JJ (2003) Examination of diverse toxin-coregulated pilus-positive Vibrio cholerae strains fails to demonstrate evidence for Vibrio pathogenicity island phage. Infect Immun 71: 2993 ... WebThe Vibrio cholerae toxin-coregulated pilus (TCP) and the enterotoxigenic Escherichia coli CFA/III pilus each mediates export of a single ... Toxin cargo genes are often horizontally transferred by phages between bacterial species and are known to play an important role in the evolution of bacterial pathogenesis. Here, we show how these same ...

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WebThe Vibrio cholerae toxin-coregulated pilus (TCP) and the enterotoxigenic Escherichia coli CFA/III pilus each mediates export of a single exoprotein, TcpF and CofJ, respectively. Here, we show that the disordered N-terminal segment of mature TcpF is the export signal (ES) recognized by TCP. Deletion of the ES disrupts secretion and causes TcpF ... WebDec 19, 2016 · TCP are members of the Type IV pilus (T4P) class, which are expressed by many Gram-negative bacteria as well as some Gram-positive species and archaea [ 12 – …

V. cholerae pathogenicity genes code for proteins directly or indirectly involved in the virulence of the bacteria. To adapt the host intestinal environment and to avoid being attacked by bile acids and antimicrobial peptides, V. cholera uses its outer membrane vesicles (OMVs). Upon entry, the bacteria sheds its OMVs, containing all the membrane modifications that make it vulnerable for the hos… WebJan 8, 2008 · The bacterial pathogen Vibrio cholerae uses toxin-coregulated pili (TCP) to colonize the human intestine, causing the severe diarrheal disease cholera. TCP are long, …

WebThe first is the toxin-coregulated pilus (TCP), which also aids the bacterium in adhering to the intestinal cell wall. The TCP is thought to bind to the minor CTXφ coat protein OrfU. The second is the TolQRA membrane protein structure. [3] WebFeb 19, 2002 · Two factors are critical to V. cholerae virulence—cholera enterotoxin (CT) and an intestinal colonization factor known as the toxin-coregulated pilus (TCP). Poorly characterized environmental cues influence the expression of CT and TCP in vivo ( 2 ).

WebFor example, the major toxin-coregulated pilus (TCP) gene, tcpA, of the TCP cluster possesses classical- and El Tor-specific alleles that encode identical functions but differ …

gelfoam how long can you leaveWebThe toxin-coregulated pilus (TCP) of Vibrio cholerae: molecular cloning of genes involved in pilus biosynthesis and evaluation of TCP as a protective antigen in the infant mouse … gel foam loveseat cushionWebOct 28, 2005 · Cholera is caused by the Gram-negative bacterium V. cholerae, which elaborates two major virulence factors, cholera toxin (CT) and the toxin coregulated pilus (TCP) ( 2 ). CT is an adenosine diphosphate–ribosylating toxin encoded in the genome of the filamentous, lysogenic CTXΦ phage. ddg aircraft