Webb11 apr. 2024 · Duong et al. based their smart system in the use of a pH-sensitive MAPs that were getting dissolved only at physiological pH to improve the results of a DNA vaccine (Duong et al., 2024). DNA polyplexes, an adjuvant and heparin were included in a triblock pH-sensitive copolymer and oligo-(sulfamethazine)-b-poly (ethyleneglycol)-b-poly-(beta … WebbAt physiological pH, the peptide–drug conjugates interact weakly with a membrane. At low pH, the peptide forms a transmembrane helix with its C -terminus inserted in the cytoplasm, the intracellular reductive environment breaks the disulfide bond to release the drug. Display full size Materials and methods Materials
E. coli Nissle 1917-Derived Minicells for Targeted Delivery of ...
Webb9 apr. 2013 · Family of pH (low) insertion peptides for tumor targeting. Cancer is a complex disease with a range of genetic and biochemical markers within and among tumors, but … WebbCCL21, a secondary lymphoid tissue chemokine, plays an important role in generating an effective anti-tumor immune response. In this study, a genetically modified CCL21 was … shannon storage castle shannon
pH-Responsive pHLIP (pH Low Insertion Peptide) Nanoclusters of ...
WebbpHLIP ® s (pH-Low Insertion Peptides) are a platform technology of pH-sensitive peptides that exploit pH differences between healthy and diseased cells as a biomarker for … Webb14 okt. 2015 · The family of pHLIP peptides with pK of insertion varying from 4.5 to 6.5 was introduced , and it was confirmed that tumor targeting is indeed pH dependent . … WebbDoctor of Biochemistry focuses on plant growth and stress management. I have over 10 years of research experience in molecular biology and plant genetics. I am not shy of a challenge and particularly enjoy working with a focused and creative team to meet goals and deadlines. I lead projects with trust and high expectations, problem-solving, and a … pomp and circumstance bpm