WebMar 31, 2024 · IRE1 is an unfolded protein response (UPR) sensor with kinase and endonuclease activity. It plays a central role in the endoplasmic reticulum (ER) stress response through unconventional splicing of XBP1 mRNA and regulated IRE1-dependent decay (RIDD). Multiple myeloma (MM) cells are known to exhibit an elevated level of … WebOct 31, 2013 · Ire1 Signaling Is Activated in the Photoreceptors during Pupal Stages To detect Ire1 signaling activity in the photoreceptors during development, we used the Xbp1-EGFP reporter ( Ryoo et al., 2007 ), in which EGFP becomes in frame with Xbp1 only upon Ire1-dependent mRNA splicing.
Dynamics and clustering of IRE1α during ER stress PNAS
WebMay 8, 2024 · Inositol-requiring transmembrane kinase endoribonuclease-1α (IRE1α) is the most prominent and evolutionarily conserved unfolded protein response (UPR) signal … WebNov 14, 2013 · Ire1 is activated in the photoreceptors during Drosophila pupal development • Ire1 mutant photoreceptors have defects in rhabdomere morphogenesis • The role of Ire1 in rhabdomere morphogenesis is independent of Xbp1 function • Regulation of fatp by RIDD is critical for rhabdomere morphogenesis Summary clothes bacteria
Getting RIDD of RNA: IRE1 in cell fate regulation - ResearchGate
WebWe conclude that regulation of fatp levels by RIDD is an important part of Ire1 role during photoreceptor differentiation in the Drosophila eye. ... View in full-text Citations The failure to... WebMay 6, 2024 · IRE1α is constitutively active in several cancers and can contribute to cancer progression. Activated IRE1α cleaves XBP1 mRNA, a key step in production of the transcription factor XBP1s. In... WebJan 4, 2012 · IRE1's RIDD activity also cleaves ER-targeted mRNAs, leading to drops in levels of some membrane and secreted proteins (Han et al., 2009; ... Probing mechanisms of photoreceptor degeneration in a new mouse model of the common form of autosomal dominant retinitis pigmentosa due to P23H opsin mutations. bypass activation lock with imei