Ctgf and fibrosis

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August undefined, 2024

WebMar 9, 2024 · p53 induces CTGF expression and promotes liver fibrosis; CTGF specifically induced the synthesis of decorin, suggesting a mechanism of autoregulation. This report provides novel evidence that CTGF confers cardioprotection by salvage phosphokinase signaling leading to inhibition of glycogen synthase kinase 3 beta, activation of phospho … WebFeb 17, 2024 · A fully recombinant human monoclonal antibody therapy has begun phase 3 assessment for the treatment of idiopathic pulmonary fibrosis (IPF). Pamrevlumab, a connective tissue growth factor (CTGF) inhibitor, is now being dosed in patients with IPF participating in the ZEPHYRUS-2 phase 3 trial.

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WebApr 13, 2024 · The identification of tissue-specific promoters for gene therapeutic constructs is one of the aims of complex tumor therapy. The genes encoding the fibroblast … WebApr 7, 2024 · TGFβ and CTGF promote fibrosis by NOTCH signaling pathway activation. Therefore, TGFβ1 and CTGF were used to activate NOTCH signaling in vitro. First, human healthy meniscus cells were treated with TGFβ1, NOTCH3 siRNA (or HEYL siRNA), or TGFβ1+NOTCH3 siRNA (or HEYL siRNA). The COL1A1 RNA levels were detected by … lithium 6 to tritium

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WebMar 10, 2024 · Renal interstitial fibrosis, an important pathological feature of kidney aging and chronic renal failure, is regulated by mesenchymal stem cells (MSCs). ... our study confirms for the first time that CTGF is a target of miR-133b and is involved in amelioration of renal fibrosis. CTGF not only potentiates TGF-β signaling by directly binding to ... WebIt is known to us that TGF-β1 plays an important role in the inflammation and fibrosis of keloid. 16 Our previous research found that adiponectin down-regulated CTGF, a downstream target factor of the TGF-β1/Smad signaling pathway, induced keloid pathogenesis. 13 However, whether adiponectin suppressed TGF-β1-induced … WebConnective tissue growth factor (CTGF) has been recognized as a central mediator and promising therapeutic target in hepatic fibrosis. In this study, we generated a novel virus-like particle (VLP ... lithium 6 symbol

Connective Tissue Growth Factor Inhibition Enhances Cardiac …

Ctgf and fibrosis

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WebConnective tissue growth factor (CTGF) plays a critical role in the hepatic stellate cells (HSCs)-mediated development of hepatic fibrosis. Nevertheless, the effects of CTGF … WebMay 8, 2024 · Connective tissue growth factor (CTGF) associated with transforming growth factor-β (TGF-β) play a pivotal role in the pathophysiology of many fibrotic …

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WebConnective Tissue Growth Factor/CCN2. CTGF is a cysteine-rich 40 kDa matricellular growth factor implicated in angiogenesis, wound healing, and development. Although it is … WebCTGF is involved in cell proliferation, migration, and differentiation and can promote the progression of fibrosis directly or act as a downstream factor of transforming growth …

WebAug 6, 2024 · CTGF expression is known to be upregulated in the extra-capillary and mesangial lesions of glomerulonephritis in human kidney biopsy samples. In addition to … WebHemizygous deletion of CTGF/CCN2 does not suffice to prevent fibrosis of the severely injured kidney Falke LL, Dendooven A, Leeuwis JW, …

WebJul 4, 2024 · Idiopathic pulmonary fibrosis (IPF) is a fatal lung disease characterized by progressive and excessive accumulation of myofibroblasts and extracellular matrix in the … WebApr 13, 2024 · The identification of tissue-specific promoters for gene therapeutic constructs is one of the aims of complex tumor therapy. The genes encoding the fibroblast activation protein (FAP) and the connective tissue growth factor (CTGF) can function in tumor-associated stromal cells but are practically inactive in normal adult cells. Accordingly, the …

Webaffect the expression of pro-fibrotic growth factor CTGF, which is known to promote collagen and fibronectin synthesis [21]. The results showed that TGF-β1-induced CTGF …

WebJul 16, 2008 · BackgroundIn proliferative diabetic retinopathy (PDR), vascular endothelial growth factor (VEGF) and connective tissue growth factor (CTGF) cause blindness by neovascularization and subsequent fibrosis, but their relative contribution to both processes is unknown. We hypothesize that the balance between levels of pro-angiogenic VEGF … improve performance on this laptopWebaffect the expression of pro-fibrotic growth factor CTGF, which is known to promote collagen and fibronectin synthesis [21]. The results showed that TGF-β1-induced CTGF expression was downregulated by KLF15 in NRK-49F cells, and KLF15 may also be a negative regulator of CTGF in renal interstitial fibrosis. improve performance of java applicationWebBiochanin-A (BCA), is an isoflavonoid, exhibits protective effects against various diseases. This study was conducted to observe the effect of BCA on isoprenaline (ISP)-induced cardiac fibrosis and explore the underlying mechanism. The curative effect of BCA was investigated with oral administration for 14 days in ISP-induced cardiac fibrosis ... lithium 6 protonsWebThe connective tissue growth factor (CTGF), a fibrogenic cytokine, is a downstream mediator of TGFβ/Smad-induced fibrosis. CTGF was found to be overexpressed in the … lithium-6 symbolWebFeb 25, 2024 · FG-3019 (pamrevlumab) is a human monoclonal antibody (mAb) against CTGF that has shown efficacy in a randomized, placebo-controlled phase 2 clinical trial in subjects with idiopathic pulmonary fibrosis , as well as in phase 2 clinical trials for treatment of pancreatic cancer and Duchenne muscular dystrophy (NCT02210559 and … improve performance of azure sql databaseWebJun 13, 2005 · Elevated production of CTGF might be responsible for maintenance of the fibrotic phenotype in scleroderma. Assays of CTGF or of its fragments are potential non-invasive measures of the fibrotic response in scleroderma. Aim: To determine the utility of whole, N-terminal, and C-terminal CTGF as surrogate markers for fibrosis in scleroderma. lithium 6 usesWebFeb 1, 2011 · Connective tissue growth factor (CTGF) is widely thought to promote the development of fibrosis in collaboration with transforming growth factor (TGF)-β; however, most of the evidence for its involvement comes from correlative and culture-based studies. In this study, the importance of CTGF in tissue fibrosis was directly examined in three … improve performance of macbook pro